Thermodynamic Analysis of the Solubility of Propylparaben in Acetonitrile–Water Cosolvent Mixtures

Parabens are substances used in the food, pharmaceutical and cosmetic industries. Recent studies have indicated that these toxic potential, cause endocrine disruption can easily bioaccumulate; therefore, their physicochemical properties of industrial, biological environmental interest. Due to potential use development more efficient cleaner processes, design recovery strategies reasonable designs for solubility cosolvent mixtures, thermodynamic analysis mathematical modeling great This research propylparaben acetonitrile + water mixtures at nine temperatures by UV/Vis spectrophotometry, analyzing solid phase differential scanning calorimetry evaluate possible polymorphic changes. The is an endothermic process, where separation occurs intermediate reaching its minimum pure 278.15 K maximum 315.15 K. experimental data well-correlated with va not Hoff, Apelblat Buchowski–Ksiazaczak models. results revealed microheterogeneity MeCN W mixture generate possibly due formation solvates or hydrates.